Mutations in Signal Sequence Cleavage Domain of Preproparathyroid Hormone Alter Protein Translocation, Signal Sequence Cleavage, and Membrane-Binding Properties
نویسندگان
چکیده
منابع مشابه
Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function.
The function of amino-terminal pro-specific peptides (propeptides), sequences often found on intermediate precursor forms of secreted proteins, is poorly understood. Human preproparathyroid hormone (prepro-PTH), a precursor protein containing such a propeptide, is initially synthesized as a precursor containing a 25-amino acid signal sequence, a 6-amino acid propeptide, and the 84-amino acid ma...
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When preparing data sets of amino acid or nucleotide sequences it is necessary to exclude redundant or homologous sequences in order to avoid overestimating the predictive performance of an algorithm. For some time methods for doing this have been available in the area of protein structure prediction. We have developed a similar procedure based on pair-wise alignments for sequences with functio...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1989
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend-3-2-240